Sex- and stage-specific reporter gene expression in Plasmodium falciparum
نویسندگان
چکیده
منابع مشابه
Shotgun DNA microarrays and stage-specific gene expression in Plasmodium falciparum malaria.
Malaria infects over 200 million individuals and kills 2 million young children every year. Understanding the biology of malarial parasites will be facilitated by DNA microarray technology, which can track global changes in gene expression under different physiological conditions. However, genomes of Plasmodium sp. (and many other important pathogenic organisms) remain to be fully sequenced so,...
متن کاملRegulation of gene expression in Plasmodium falciparum
With the ability to adopt an assortment of forms throughout its life cycle, and to thrive in host environments so diverse and challenging, the malaria parasite Plasmodium falciparum may well serve as the epitome of the regulation of gene expression. The parasite is replete with mechanisms of control, many of them unique and intriguing, permitting it to transit seamlessly from one defined ecolog...
متن کاملShotgun DNA microarrays and stage-speci®c gene expression in Plasmodium falciparum malaria
Rhian E. Hayward, Joseph L. DeRisi, Suad Alfadhli, David C. Kaslow, Patrick O. Brown and Pradipsinh K. Rathod* Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA. Department of Biochemistry, University of California San Francisco, San Francisco, CA 94143-0448, USA. Department of Biochemistry, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, C...
متن کاملIdentification of three stage-specific proteinases of Plasmodium falciparum
We have identified and characterized three stage-specific proteinases of Plasmodium falciparum that are active at neutral pH. We analyzed ring-, trophozoite-, schizont-, and merozoite-stage parasites by gelatin substrate PAGE and characterized the identified proteinases with class-specific proteinase inhibitors. No proteinase activity was detected with rings. Trophozoites had a 28 kD proteinase...
متن کاملPfmrk, a MO15-related protein kinase from Plasmodium falciparum. Gene cloning, sequence, stage-specific expression and chromosome localization.
Cyclin-dependent kinases (Cdks) play a central role in the regulation of the eukaryotic cell cycle. A novel gene encoding a Cdk-like protein, Pfmrk, has been isolated from the human malaria parasite Plasmodium falciparum. The gene has no introns and comprises an open reading frame encoding a protein of 324 amino acids with a predicted molecular mass of 38 kDa. Database searches revealed a strik...
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ژورنال
عنوان ژورنال: Molecular and Biochemical Parasitology
سال: 2008
ISSN: 0166-6851
DOI: 10.1016/j.molbiopara.2008.04.005